Publications

Liu S#, Tafoya S, Bustamante C#. (2017) Deciphering the molecular mechanism of the bacteriophage φ29 DNA packaging motor. Methods Mol. Biol. 1486:343—355.
Web

Liu S*, Chistol G*, Hetherington CL*, Tafoya S, Aathavan K, Schnitzbauer J, Grimes S, Jardine PJ, Bustamante C. (2014) A viral packaging motor varies its DNA rotation and step size to preserve subunit coordination as the capsid fills. Cell 157:702—713.
Web   PDF
LBNL News Center: “All in the rotation”

Liu S*, Chistol G*, Bustamante C. (2014) Mechanical operation and intersubunit coordination of ring-shaped molecular motors: insights from single-molecule studies. Biophys. J. 106:1844—1858. Review.
Web   PDF

Dangkulwanich M*, Ishibashi T*, Liu S*, Kireeva ML, Lubkowska L, Kashlev M, Bustamante C. (2013) Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism. eLife 2:e00971.
Web   PDF
eLife Insight: “On the move”

Chistol G*, Liu S*, Hetherington CL, Moffitt JR, Grimes S, Jardine PJ, Bustamante C. (2012) High degree of coordination and division of labor among subunits in a homomeric ring ATPase. Cell 151:1017—1028.
Web   PDF
F1000Prime Recommendation

Liu S*, Harada BT*, Miller JT, Le Grice SF, Zhuang X. (2010) Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription. Nat. Struct. Mol. Biol. 17:1453—1460.
Web   PDF

Liu S, Abbondanzieri EA, Rausch JW, Le Grice SF, Zhuang X. (2008) Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates. Science 322:1092—1097.
Web   PDF
Science Perspective: “RT slides home…”
HHMI News: “An HIV enzyme with a flair for the acrobatic”
C&EN News: “Acrobatic HIV enzyme caught in action”

Liu S, Bokinsky G, Walter NG, Zhuang X. (2007) Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic “fingerprinting”. Proc. Natl. Acad. Sci. USA 104:12634—12639.
Web   PDF

Cheng B, Wu S, Liu S, Rodriguez-Aliaga P, Yu J, Cui S. (2015) Protein denaturation at a single-molecule level: the effect of nonpolar environments and its implications on the unfolding mechanism by proteases. Nanoscale 7:2970—2977.
Web   PDF

Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O’Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF. (2010) Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrob. Agents Chemother. 54:3913—3921.
Web   PDF

Rausch JW, Abbondanzieri EA, Liu S, Zhuang X, Le Grice SF. (2010) Retrovirus replication: new perspectives on enzyme and substrate dynamics. In Recent Advances in Human Retroviruses: Principles of Replication and Pathogenesis (eds. Lever A, Jeang KT, Berkhout B. World Scientific) pp. 307—343. Book Chapter.
Web  

Bokinsky G, Nivón LG, Liu S, Chai G, Hong M, Weeks KM, Zhuang X. (2006) Two distinct binding modes of a protein cofactor with its target RNA. J. Mol. Biol. 361:771—784.
Web   PDF

Song Z, Liu S, He H, Hoti N, Wang Y, Feng S, Wu M. (2004) A single amino acid change (Asp53→Ala53) converts Survivin from anti-apoptotic to pro-apoptotic. Mol. Biol. Cell 15:1287—1296.
Web   PDF

 

Featured Publications (*equal contribution): Liu S#, Tafoya S, Bustamante C#. (2017) Deciphering the molecular mechanism of the bacteriophage φ29 DNA packaging motor.